Page 9 - أبحاث كلية الصيدلة 2016-2020

2016 Publications

Pharmazie 71 (2016)

Investigation in W/O developed microemulsions with DMSO as a cosurfactant

J. ALYOUSSEF ALKRAD, A. SHUKLA, Y. MRESTANI, R. H. H. NEUBERT

In this study the effect of dimethylsulfoxide (DMSO) radii on the droplets and on the
required non-ionic surfactant volume for preparing water-in-oil microemulsions (MEs)
was investigated. Five series of MEs were prepared either with the aid of
isopropylpalmitate or medium chain triglycerides (MCTG) as continuous phases. The
MEs were stabilized via either Tween®80 or Span®20 or a mixture of both. A mixture
of water:DMSO (W:DMSO) with different ratios formed the colloidal phase of the first
four MEs series. Only DMSO was used as colloidal phase of the fifth series. Dynamic
light scattering (DLS) was used for measuring the radii of the droplets of MEs. The
results showed that the consumed volumes of the surfactants were related to the
W:DMSO ratio and the surfactant type. Moreover, the consumed surfactant volumes
increased with decreasing radii of the droplets of the MEs. The MEs stabilized with
Span®20 had lower radii of the droplets (4-15 nm) than MEs stabilized by Tween80
(25-65 nm). It was evident that DMSO changed the interfacial tension which is
reflected by changing the volume of the surfactant consumed and by altering the
droplets sizes. Consequently, DMSO acted as co-surfactant in stabilizing the MEs by
reducing the required volumes of the surfactant which is important for reducing their
toxicity.

https://pubmed.ncbi.nlm.nih.gov/27348969/

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