Page 8 - أبحاث كلية الصيدلة 2016-2020

2016 Publications

POLYMER COMPOSITES—2016

Preparation of Chitosan Nanoparticles as a Drug Delivery System for Perindopril
Erbumine

Samer Hasan Hussein-Al-Ali, Aminu Kura, Mohd Zobir Hussein, Sharida Fakurazi

Chitosan nanoparticles (CSNPs) and perindopril erbumine (PE)-loaded chitosan
nanoparticles (PE-CSNPs) were prepared using the ionic gelation method with
tripolyphosphate (TPP) as a crosslinking agent. The XRD pattern of the PE-CSNP
nanocomposite shows suppression of the peaks corresponding to crystallized chitosan
due to its conversion to the amorphous form after crosslinking and PE loading. The
presence of the drug in the nanocomposite was confirmed by a shift in the FTIR
transmittance peak from 1,289 to 1,279 cm-1. The mean diameter of the PE-CSNP
nanocomposite was 44 nm. Analysis of the ultraviolet spectrum indicated that the
loading efficiency and the encapsulation efficiency were 30.5% and 94.1%,
respectively. The in vitro drug release profile was also determined by ultraviolet
spectroscopy, which showed a sustained release over a period of 2 h (99.8%), starting
with initial burst release (40% in 10 minutes). According to our results, no IC50 (the half
maximal inhibitory concentration) against the 3T3 cell line was found for free PF or the
PE-CSNP nanocomposite up to 100 mg/ mL.

https://onlinelibrary.wiley.com/doi/full/10.1002/pc.23967

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